VEGFA splicing: divergent isoforms regulate spermatogonial stem cell maintenance
نویسندگان
چکیده
منابع مشابه
VEGFA family isoforms regulate spermatogonial stem cell homeostasis in vivo.
The objective of the present study was to investigate vascular endothelial growth factor A (VEGFA) isoform regulation of cell fate decisions of spermatogonial stem cells (SSC) in vivo. The expression pattern and cell-specific distribution of VEGF isoforms, receptors, and coreceptors during testis development postnatal d 1-180 suggest a nonvascular function for VEGF regulation of early germ cell...
متن کاملStem cell maintenance: aMPLe splicing choices.
OTT was first identified as part of the recurrent t(1;22) translocation in acute megakaryoblastic leukemia (AMKL) and was called OTT for “one twenty-two.” OTT1 is also known as RNA binding motif protein 15 (RBM15). Like other RNA binding motif proteins, RBM15 contains RNA recognition motifs (RRMs), 3 in total, which can bind to RNA and, at least for some RRMs, may also bind to DNA. Lifelong mai...
متن کاملDefining the spermatogonial stem cell.
Through the use of donor cells from transgenic rats expressing GFP exclusively in the germline, we have defined culture conditions where male germ cells lose (on STO cells) or maintain (on MSC-1 cells) stem cell activity. A cadre of germ cell transcripts strikingly decrease in relative abundance as a function of testis age or culture time on STO cells, but only a subset of these transcripts (ap...
متن کاملSpermatogonial Stem Cell Niche and Spermatogonial Stem Cell Transplantation in Zebrafish
BACKGROUND Spermatogonial stem cells (SSCs) are the foundation of spermatogenesis, and reside within a specific microenvironment in the testes called "niche" which regulates stem cell properties, such as, self-renewal, pluripotency, quiescence and their ability to differentiate. METHODOLOGY/PRINCIPAL FINDINGS Here, we introduce zebrafish as a new model for the study of SSCs in vertebrates. Us...
متن کاملSpermatogonial stem cell isolation, storage, and transplantation.
The past 30 years have been marked by unparalleled accomplishments in the medical treatment of malignancy. Prior to advances in chemotherapeutic and radiation treatment, many oncologic conditions had dismal survival rates. Today, medical interventions have success rates that approach complete remission for many malignancies. An inadvertent complication of these therapies, however, has been the ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell and Tissue Research
سال: 2015
ISSN: 0302-766X,1432-0878
DOI: 10.1007/s00441-015-2297-2